Two of the key games of the day as Pac-12 powers travel south to face top SEC East teams. No. 11 Oregon heads to Atlanta to face the defending national champions as No. 3 Georgia looks to unseat former defensive coordinator Dan Lanning, now the Ducks’ leader. No. 7 Utah, the defending Pac-12 champion and a favorite to repeat as conference title winners, travels to The Swamp where Florida hopes one of the toughest environments in college football will go a long way in the coach’s first game Billy Napier with the Gators. And then there’s the nightcap, the only top-five matchup of the first few weeks as No. 2 Ohio State hosts No. 5 Notre Dame. With three Heisman Trophy contenders and a slew of national championships, the Buckeyes will look to stop a Fighting Irish program aiming to maintain a high level of play under new coach Marcus Freeman. While winning is all that matters for the standings, we’re interested in how these games pan out in terms of odds. Be sure to stay with CBS Sports all day for college football coverage from kickoff and beyond. Let’s take a look at our experts’ picks for Saturday’s best games in Week 1. Odds via Caesars Sportsbook | All weather Eastern

Arizona at San Diego State

                Featured Game |  San Diego State Aztecs vs Arizona Wildcats

3:30 pm | CBS, CBSSports.com, CBS Sports App — This matchup features two programs from opposite ends of the competitiveness spectrum that could meet in the middle in San Diego. The Wildcats are betting big on recruiting and transfers that are quickly turning the roster around. San Diego State is confident that a new quarterback transfer, Braxton Burmeister, and key players on defense can sustain a top-25 performance. The high-powered Wildcats will have enough power plays to keep things close in a low-scoring affair. Prediction: Arizona (+6) — Shehan Jeyarajah

No. 3 Georgia vs. No. 11 Oregon (Atlanta)

                Featured Game |  Georgia Bulldogs vs. Oregon Ducks

3:30 pm | ABC, fuboTV (Try Free) — The hangover from last year’s Indianapolis title is long gone. Georgia will show they are not going to get complacent and dominate Oregon in what should be a de facto home game. Dan Lanning knows how to attack Georgia’s offensive staff, but stopping him will be a much bigger problem. Look for Georgia to come out on a mission early, wear down Oregon and root for the Ducks in the fourth quarter to pull away and cover. Prediction: Georgia (-17) — Barrett Sully

No. 23 Cincinnati at No. 19 Arkansas

                Featured Game |  Arkansas Razorbacks vs. Cincinnati Bearcats

3:30 p.m. ESPN, fuboTV (Try Free) — This is a weird situation for me because I don’t think Cincinnati leaving in 2022 will be drastic, nor do I think Arkansas is as good as many others. However, I’m taking the Razorbacks against the spread here because, while I expect the Bearcats to be one of the best five teams in the country, it’s the first game of the season that they have to replace nine NFL Draft picks, including their starting quarterback. Arkansas’ experience and home field advantage will win out in the end. Prediction: Arkansas -6.5 — Tom Fornelli

No. 7 Utah at Florida

                Featured Game |  Florida Gators vs. Utah Utes

7 pm | ESPN, fuboTV (Try Free) — The Utes are entering a breakout year as the Gators enter Year 1 of a rebuild, and the stakes have never been higher for the visitors. While there is a significant recruiting gap between these two programs, Utah has not shied away from recruiting stars in the past. In the Rose Bowl, he reached the Ohio boundary. The Utes also crushed Oregon twice to destroy the Ducks’ College Football Playoff case. Consider this a historic win for the program. Prediction: Utah -3 — Shehan Jeyarajah

No. 5 Notre Dame at No. 2 Ohio State

                Featured Game |  Ohio State Buckeyes vs. Notre Dame Fighting Irish

7:30 pm | ABC, fuboTV (Try Free) — In a vacuum or a simulation, Ohio State wins this game by 20 points, but college football is played by people and the stage is too big to believe there will be a blowout in Saturday night. The Buckeyes play with all the pressure and there have been some nightmare nights in non-conference play in Columbus, Ohio. Ultimately, Ohio State is clearly the better team and will win, but this game is an interesting one for the Fighting Irish to cover. Prediction: Notre Dame +17.5 — Chip Patterson Which college football picks can you confidently make in Week 1 and which heavy favorite will fall hard? Visit SportsLine to see which teams will win and cover the spread — all from a proven computer model that has returned nearly $3,600 in profit over the past six-plus seasons — and find out.